AestheFill® uses substances registered under GRAS (Generally Recognized as Safe) approved by the FDA and demonstrates their internationally proven safety by complying with international regulations in more than 20 countries worldwide.
Our excellent process and biocompatible polymer make us the most effective wrinkle improvement and body contouring filler, with minimal side effects and allergic reactions.
The injected filler continues to stimulate collagen production, while PDLLA is slowly metabolized naturally within the body over 24 months and excreted as carbon dioxide and water.
Our skilled doctors can perform procedures on any area that requires volume, and over a span of24 months, PDLLA gradually breaks down, promoting the natural production of collagen and resulting in a highly natural volume.
Achieve a highly satisfying and naturally enhanced appearance through a simple procedure that involves minimal risk of complications.
Thanks to our specialized technical expertise, the entire procedure is streamlined, and the ease of dilution with sterile water not only facilitates the injection process but also simplifies post-treatment care.
PDLLA (Poly-D, L-Lactic Acid) is an aliphatic thermoplastic polymer derived from 100% renewable resources, such as corn and potato starch. It is widely used in the medical industry (injectables, bio-degradable dental implants & slow-release drugs) with high safety.
Lactic acid has two optical isomers, L-lactic acid and D-lactic acid, with nearly identical chemical and physical properties. PDLLA (Poly-D, L-lactic acid) is formed through polymerization.
Optical Isomers: have the same molecular formula, but have a different arrangement of the atoms.
The development of PDLLA began in 2003 through a Korean government project that involved six national universities, including KAIST, known as the top science university in Korea.
An extensive 8-year development and clinical study was conducted under the oversight and reporting to the Ministry of Economic and Science. ref.2011.10 "Hyper-extension of adaptable human tissue engineering on bio molecular science for cell-reconstruction.
01. AestheFill® utilizes FDA-approved GRAS (Generally Recognized as Safe) substances and demonstrates their internationally proven safety by conforming to international regulations in more than 20 countries worldwide.
02. Our outstanding manufacturing process and biocompatible polymer make us the top choice for reducing wrinkles and enhancing body contours, with very few side effects or allergic reactions.
03. Biodegradable: Through hydrolysis, PDLLA is decomposed into C02 and H20, and is excreted outside the body.
04. PDLLA stays in place without migrating into surrounding tissues post-injection.
AestheFill8 , an injectable PDLLA, leads the way in aesthetic medicine, setting the highest standards in biotechnology. It is a biocompatible, biodegradable, bio-stimulatory, and long-lasting substance that heralds a new era of collagen stimulation, with the added convenience of a simple reconstitution step before use. Clinical resu Its shows volume and texture improvement Over 20 months maximum 24 months (2 years).
Injectable Poly-D, L-lactic Acid in Facial Rejuvenation: Three Case Reports. Jui-Yu Lin and Chuan-Yuan Lin. Cosmetol J 2020, 4(1): 000120.
Production of new tissues confirmed by histological analysis.
• At Week 2 after injection, cells have grown and attached on the surface of PDLLA particles and to spaces between particles. The empty spaces between particles have been filled with cells.
• At Week 8, there are no empty spaces between PDLLA particles, by being filled with cells which start to move into porous PDLLA particles (yellow arrow).
• At Week 12 and 20, cells have moved into the inner parts of PDLLA particles, and fill inside and spaces between the particles.
Production of new tissues confirmed by histological analysis.
• From Week 4, new collagen has been generated by the cells settled in the PDLLA.
• At Week 12 and 20, collagen expression increased between porous PDLLA particles and inside the particles (yellow arrows).
AestheFill® is PDLLA(Poly-D, L-Lactic Acid), polymerized optical isomer for dermal injection. Class Ill Medical Device for injection on overall face to improve skin quality, texture, and wrinkles that will last up to 24-36 months by giving natural effects of collagen stimulation.
*Aesthefill® Clinical Study Report_2014-2022.
The natural result of AestheFill® will be gradually seen over the stages up to 24- 36 months helping to regenerate and stimulate own collagen which helps to show a plumped and refreshed appearance with a long-lasting result.
Aside from the immediate effects observed right after injection, following reconstitution with sterilized water, collagen regeneration and stimulation require time. The timeline can vary depending on the patient's individual condition, but on average, noticeable results such as improved skin texture can be seen within 5 to 10 days as stimulation initiates around the injected area.
The regenerative process continues over the next few weeks reaching its expected and best outcome at approximately 3 months post-injection. This sustained improvement enhances overall skin quality, texture, and reduces wrinkles, yielding results that endure for over two years.
AestheFill® is treated only by medical practitioners who are fully trained and certified by AestheFill Academy worldwide by different category of classes for various indications. Visit our website www.aesthefill.beauty and sign up for latest news as Regional Workshops nearby, Congress information, Latest news, Clinical Updates, and journals.
*Μέσος όρος θεραπευτικού στόχου από 20-70 ετών.
Recommendation has been built based on our clinical data by using over age of 20 (twenty) who are looking for long-lasting and natural results. All ages of treatment are very effective and it will help the patient stimulate collagen better the younger.
*Avg. treating target from 20-70 years old.
To obtain an optimal result, a complete treatment of 3 session is recommended. It can be extended or reduced based on patient condition. The time interval between each session would be 4- 6weeks.
In 2014, AestheFill® obtained its initial KFDA approval, marking its official introduction into the South Korean market. Since then, it has achieved compliance in over 50 countries worldwide, including CE (EC), ANVISA, INVIMA, and GOST-R, enabling its sales and distribution.
Challenge is the drive we keep seeking in global market by having new opportunities not just repeating with good solutions but sharing our insights with our partners and masters. Plla(Poly Llactic acid) has been in medical market more than 50 years where this new challenge hasn't been brought up for the past decades. Our solution brings a truly unique biotechnology, turning plla into PDLLA(Poly-D, L-lactic acid) based on our pure technology of patent BPM(Biodegradable polymer microparticles), postpolymerization treatments.
*US COBF6/00.
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